(S,R,S)-AHPC-C2-PEG4-N3

SKU: orb1987763

Description

(S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a VHL E3 ligase ligand-linker conjugate used to construct PROTAC molecules for targeted protein degradation. It serves as a key component in degraders like vRucaparib-TP4, a potent PARP1 degrader with a DC50 of 82 nM, applicable in both in vitro and cellular degradation studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• MW: 703.85
• Formula: C₃₃H₄₉N₇O₈S
• SMILES: CC(C)([C@H](NC(CCOCCOCCOCCOCCN=[N+]=[N-])=O)C(N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)C
• Target: E3 Ligase Ligand-Linker Conjugates,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

145994564