SR2211

SKU: orb1706605

Description

SR2211 is a potent and selective inverse agonist of the nuclear receptor RORγ, exhibiting an IC50 of 320 nM and a Ki of 105 nM. This small molecule is a valuable research tool for studying Th17 cell biology, autoimmune diseases, and cancer in both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1359164-11-6
• MW: 527.48
• Purity: 98.75% (May vary between batches)
• Formula: C₂₆H₂₄F₇N₃O
• SMILES: OC(c1ccc(c(F)c1)-c1ccc(CN2CCN(Cc3ccncc3)CC2)cc1)(C(F)(F)F)C(F)(F)F
• Target: ROR
• Solubility: DMSO:90 mg/mL (170.62 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (6.26 mM)

Bioactivity

• Target IC50:
  RORγ:320 nM|RORγ:105 nM(ki)
• In Vitro:
  In EL-4 cells, SR2211 inhibits the expression of IL-23 receptor and IL-17 intracellular staining.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RORγ, SR 2211, SR2211, SR-2211

Compound Identifiers

PubChem CID

51035449