SR12813

SKU: orb1300278

Description

SR12813

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 126411-39-0
• MW: 504.53
• Purity: 99.43%
• Formula: C₂₄H₄₂O₇P₂
• SMILES: P(C(P(OCC)(OCC)=O)=CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)(OCC)(OCC)=O
• Target: Autophagy,HMG-CoA Reductase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.96 mM);Ethanol:50.5 mg/mL (100.09 mM);DMSO:50.5 mg/mL (100.09 mM)

Bioactivity

• Target IC50:
  HMG-CoA reductase:850 nM
• In Vivo:
  The bisphosphonate ester SR12813 lowers cholesterol levels in a range of species including rats, dogs and primates.
• In Vitro:
  SR12813 is a very potent and efficacious activator of both the human and rabbit PXR, with EC50 values of approximately 200 nM and 700 nM, respectively. By contrast, SR12813 is only a very weak activator of the rat and mouse PXR. SR-12813 inhibits incorporation of tritiated water into cholesterol with an IC50 of 1.2 μM but has no effect on fatty acid synthesis. SR-12813 reduces cellular 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity with an IC50 of 0.85 μM. The inhibition of HMG-CoA reductase activity is rapid with a T1/2 of 10 min.
• Cell Research:
  Hep G2 cells are incubated for 21 h with either 1 μM lovastatin or 3 μM SR-12813 in 5% LPDS medium. mRNA is isolated and analyzed by Northern blotting.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, GW 485801, GW485801, GW-485801, HMG-CoA Reductase (HMGCR), HMGCoAReductase, HMGCR, HMGCoA Reductase, HMG-CoA reductase, Inhibitor, inhibit, SR 12813, SR12813, SR-12813

Compound Identifiers

PubChem CID

446313