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SR-4370

SKU: orb1223226

Description

SR- 4370 is an HDAC inhibitor. SR- 4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp. SR- 4370 is reported in WO 2015153516.

Images & Validation

Key Properties

CAS Number1816294-67-3
MW304.34
Purity>98% (HPLC)
FormulaC17H18F2N2O
SMILESFc1c(cccc1F)c2ccc(cc2)C(=O)NNCCCC
TargetGPR
SolubilityDMSO : ≥ 150 mg/mL; 492.89 mM

Bioactivity

In Vitro
SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively. SR-4370 is cytotoxic to the breast cancer cells (MDA-MB-231), with an IC50 of 12.6 μM.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SR-4370 | SR 4370 | SR4370

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Protocol Information

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