Squalene

SKU: orb1302594

Description

Squalene (AddaVax) is a cholesterol biosynthesis intermediate with demonstrated pharmacological potential. It is investigated in research for its antilipemic, antioxidant, and hepatoprotective properties, with applications in studies of atherosclerosis, cardioprotection, and antitumor activity in both in vitro and in vivo models.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 111-02-4
• MW: 410.72
• Purity: 99.33%
• Formula: C₃₀H₅₀
• SMILES: CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C
• Target: Antifungal,Endogenous Metabolite,Reactive Oxygen Species,ROS
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.03 mM);Ethanol:100 mg/mL (243.47 mM);DMSO:100 mg/mL (243.47 mM)

Bioactivity

• Target IC50:
  HepG2 cells:100 μg/ml|JURKAT cells:26.22 μg/ml
• In Vivo:
  METHODS: To study the effect of Squalene on lipid parameters, mice were fed a diet containing Squalene (0.25-1 g/kg) for 11 weeks. RESULTS: Squalene promoted the changes of HDL-cholesterol and paraoxonase 1, and decreased the reactive oxygen species in lipoproteins and plasma malondialdehyde levels.
• In Vitro:
  METHODS: Human MCF7, NCI-H460, and SF-268 cells were treated with Squalene (0-50 μM) for 72 hours, and MTS reduction assay was used to detect cell growth inhibition. RESULTS: Squalene did not inhibit the proliferation of MCF7, NCI-H460 and SF-268 cells (IC50>50 μM). METHODS: MCF10A epithelial cells were treated with Squalene (12.5, 50, and 200 μM) for 24 hours, and ROS levels were measured using a microplate reader. RESULTS: Squalene reduced intracellular ROS levels.

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Reactive Oxygen Species, ReactiveOxygenSpecies, Super Squalene, Squalene, AddaVax, Endogenous Metabolite, Fungal, EndogenousMetabolite

Compound Identifiers

PubChem CID

1105