Spironolactone

SKU: orb1310575

Description

Spironolactone (SC9420) is a steroidal aldosterone antagonist used extensively in research to study mineralocorticoid receptor function. It is applied in both in vitro binding assays and in vivo models of hypertension, heart failure, and renal disease.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 52-01-7
• MW: 416.57
• Purity: 99.63% (May vary between batches)
• Formula: C₂₄H₃₂O₄S
• SMILES: C[C@@]12[C@]3(CC[C@]1([C@]4([C@](CC2)([C@]5(C)C(C[C@H]4SC(C)=O)=CC(=O)CC5)[H])[H])[H])OC(=O)CC3
• Target: Autophagy,Calcium Channel,Androgen Receptor,Glucocorticoid Receptor
• Solubility: Ethanol:20.8 mg/mL (49.93 mM);DMSO:250 mg/mL (600.14 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.8 mM)

Bioactivity

• Target IC50:
  Androgen receptor:77 nM
• In Vivo:
  Spironolactone inhibits the specific binding of stanozololone in the nucleus and prostate cytoplasm of the rat prostate.Spironolactone is a strong AR antagonist with an IC50 of 77 nM, a weak GR antagonist with an IC50 of 2.4 μM, and a weak PR agonist with an EC50 of 740 nM.
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• In Vitro:
  Spironolactone inhibits the specific binding of stanozololone in the nucleus and prostate cytoplasm of the rat prostate.Spironolactone is a strong AR antagonist with an IC50 of 77 nM, a weak GR antagonist with an IC50 of 2.4 μM, and a weak PR agonist with an EC50 of 740 nM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

diabetic, Abbolactone, Androgen Receptor, AndrogenReceptor, Autophagy, Inhibitor, inhibit, Mineralocorticoid Receptor, oral, nephropathy, GlucocorticoidReceptor, Glucocorticoid Receptor, selective, podocytes, Spironolactone, SC 9420, SC9420, SC-9420

Compound Identifiers

PubChem CID

5833