Spiroglumide

SKU: orb1745201

Description

Spiroglumide is a selective CCKB/gastrin receptor antagonist used to investigate gastrin's physiological role in gastric acid secretion. It effectively inhibits pentagastrin-induced acid hypersecretion in vivo with an ID50 of 20.1 mg/kg, making it a valuable research tool for studying gastrointestinal physiology and related disorders.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 137795-35-8
• MW: 441.35
• Purity: 98.04% (May vary between batches)
• Formula: C₂₁H₂₆Cl₂N₂O₄
• SMILES: C([C@H](NC(=O)C1=CC(Cl)=CC(Cl)=C1)CCC(O)=O)(=O)N2CCC3(CC2)CCCC3
• Target: Cholecystokinin Receptor
• Solubility: DMSO:50 mg/mL (113.29 mM)

Bioactivity

• In Vivo:
  Spiroglumide (25、50、75、100 mg/kg; rat) dose-dependent inhibition of pentagastrin (16 µg/kg/h) induced acid hypersecretion.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CCK, CR-2194, CR2194, CR 2194, Spiroglumide

Compound Identifiers

PubChem CID

65987