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Sotorasib

SKU: orb1220193

Description

Sotorasib (AMG-510) racemate is the racemate of Sotorasib (AMG-510). AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity.

Images & Validation

Key Properties

CAS Number2252403-56-6
MW560.59
Purity>98% (HPLC)
FormulaC??H??F?N?O?
TargetRas
SolubilityDMSO : 3.85 mg/mL (6.87 mM; Need ultrasonic)

Bioactivity

In Vivo
Animal model: Female NOD/SCID mice, tumor xenograft model of NCI-H358 cells which harbor KRAS G12C (human NSCLC cell). Dosage: 10, 30, 100 mg/kg. Administration: Oral gavage (p.o.), QD for 21 d. Result: Suppressed the growth of the NCI-H358 tumors in a dose-dependent manner, observed significant tumor regression at 100 mg/kg and 30 mg/kg with tumor growth inhibition of 137% and 126%, respectively.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AMG-510 racemate

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Protocol Information

Sotorasib (orb1220193)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 70.00
5 mg
$ 90.00
10 mg
$ 130.00
25 mg
$ 230.00
50 mg
$ 400.00
100 mg
$ 610.00
500 mg
$ 1,290.00