Sorivudine

SKU: orb1307733

Description

Sorivudine (BV-araU) is a nucleoside analog antiviral agent that inhibits the replication of VZV, HSV-1, and EBV by targeting viral DNA synthesis. It is used in research applications, including in vitro antiviral assays and in vivo models for studying herpesvirus infections and antiviral mechanisms.

Research Area

Cell Biology, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 77181-69-2
• MW: 349.13
• Purity: 97.33% (May vary between batches)
• Formula: C₁₁H₁₃BrN₂O₆
• SMILES: OC[C@H]1O[C@H]([C@@H](O)[C@@H]1O)n1cc(\C=C\Br)c(=O)[nH]c1=O
• Target: DNA/RNA Synthesis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.46 mM);DMSO:125 mg/mL (358.03 mM)

Bioactivity

• In Vivo:
  Sorivudine has been evaluated in the treatment of HSV-l encephalitis when administered orally to mice. The survival of treated mice is prolonged at dosages in excess of 12.5 mg/kg. A significant decrease in mortality was achieved as well with doses in excess of 50 mg/kg. Sorivudine therapy at dosages as low as 20 mg/kg per day given intramuscularly or 100 mg/kg per day administered orally completely protected against viremia and mortality. There was no evidence of neurotoxicity or abnormalities in hematology or clinical chemistries. Doses as low as 0.2 mg/kg per day were effective; however, breakthrough viremia was noted at lower dosages .
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• In Vitro:
  Sorivudine inhibits strains of HSV-1 and HSV-2 (ID50s (50% inhibitory dose): 0.39 and 0.67 μM, respectively). Sorivudine has antiviral activity against several viruses including varicella-zoster virus, herpes simplex type 1 virus, and Epstein-Barr virus. Sorivudine has in vitro inhibitory activity against the varicella-zoster virus at concentrations of 00001-0.004 mg/ml. These concentrations are over 1000-fold lower than those which are required for the inhibition of VZV replication by acyclovir 3 Sorivudine also inhibits HSV-I replication at concentrations ranging from 0.03-0.1 mg/ml .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antimetabolite, antiviral, BV-araU, DNASynthesis, DNA Synthesis, DNA synthesis, DNA/RNA Synthesis, oral, pyrimidine, nucleoside, inhibit, Epstein-Barr, herpes, Inhibitor, simplex, RNA Synthesis, RNASynthesis, Sorivudine, zoster, type, varicella, virus

Compound Identifiers

PubChem CID

5282192