Solifenacin

SKU: orb1299178

Description

Solifenacin (YM905 free base) is a selective muscarinic receptor antagonist with pKi values of 7.6 (M1), 6.9 (M2), and 8.0 (M3). It is widely used in pharmacological research for in vitro receptor binding assays and in vivo studies investigating urinary bladder function and overactive bladder pathways.

Research Area

Neuroscience

Key Properties

• CAS Number: 242478-37-1
• MW: 362.46
• Purity: 99.91% (May vary between batches)
• Formula: C₂₃H₂₆N₂O₂
• SMILES: C(O[C@@H]1C2CCN(C1)CC2)(=O)N3[C@H](C=4C(CC3)=CC=CC4)C5=CC=CC=C5
• Target: AChR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.52 mM);H2O:< 0.1 mg/mL (insoluble);DMSO:55 mg/mL (151.74 mM)

Bioactivity

• Target IC50:
  M3 mAChR:8 (ki)|M2 mAChR:6.9 (ki)|M1 mAChR:7.6 (ki)
• In Vivo:
  Solifenacin exerts minimal inhibitory effects on salivary and cardiac responses at a dosage of 630 nmol/kg (0.3 mg/kg), achieving inhibition levels of 66% and 49%, respectively, at 2100 nmol/kg (1 mg/kg). At lower doses (63 and 210 nmol/kg or 0.03 and 0.1 mg/kg), Solifenacin slightly enhances saliva secretion. Conversely, it reduces bladder responses by 40% at 210 nmol/kg (0.1 mg/kg) and completely suppresses them at 2100 nmol/kg (1 mg/kg). Intravenously administered, Solifenacin (0.01 to 0.3 mg/kg) progressively augments bladder capacity and the volume of urine voided when dosed at 0.03 mg/kg or higher, without impacting residual volume or micturition pressure at any administered dosage.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Muscarinic acetylcholine receptor, muscarinic receptor, inhibit, mAChR, Inhibitor, Solifenacin, YM 905, YM905, YM-905, YM905 free base

Compound Identifiers

PubChem CID

154059