SNIPER(BRD)-1

SKU: orb1988923

Description

SNIPER(BRD)-1 is a heterobifunctional degrader molecule that links a derivative of the IAP antagonist LCL-161 to the BET inhibitor (+)-JQ-1. It induces potent degradation of BRD4 and IAP family proteins (cIAP1, cIAP2, XIAP) via the ubiquitin-proteasome system, serving as a valuable chemical probe for studying protein degradation and oncology research in cellular models.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2095244-54-3
• MW: 1056.73
• Formula: C₅₃H₆₆ClN₉O₈S₂
• SMILES: CC=1C2=C(N3C([C@H](CC(NCCOCCOCCOCCOC4=CC(C(=O)C=5N=C(SC5)[C@]6(N(C([C@@H](NC([C@@H](NC)C)=O)C7CCCCC7)=O)CCC6)[H])=CC=C4)=O)N=C2C8=CC=C(Cl)C=C8)=NN=C3C)SC1C
• Target: Epigenetic Reader Domain,Others,SNIPERs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

138377573