Snail/HDAC-IN-1

SKU: orb1686782

Description

Snail/HDAC-IN-1

Research Area

Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Molecular Biology, Stem Cell & Developmental Biology; Epigenetics & Chromatin

Key Properties

• CAS Number: 2415281-52-4
• MW: 488.54
• Purity: 97.00% (May vary between batches)
• Formula: C₂₄H₂₁FN₈OS
• SMILES: O=C(NC1=CC=C(F)C=C1N)C2=CC=C(C=C2)CSC=3N=C(NC4=NNC(=C4)C)C5=CC=CN5N3
• Target: Apoptosis,HDAC,Antifungal
• Solubility: DMSO:100 mg/mL (204.69 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (6.75 mM)

Bioactivity

• Target IC50:
  Colon HCT 116 cells:0.0751 μM|HDAC1:0.405 μM
• In Vitro:
  Snail/HDAC-IN-1 exhibited the most potent inhibitory activity against HDAC1 with an IC50 of 0.405 μM, potent inhibition against Snail with a Kd of 0.180 μM, and antiproliferative activity in HCT-116 cell lines with an IC50 of 0.0751 μM. Snail/HDAC-IN-1 showed good inhibitory effects on NCI-H522 (GI50 = 0.0488 μM), MDA-MB-435 (GI50 = 0.0361 μM), and MCF7 (GI50 = 0.0518 μM).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, Antifungal

Compound Identifiers

PubChem CID

153528580