SMD-1087

SKU: orb2944974

Description

SMD-1087 is a potent and selective SMARCA2 PROTAC degrader (DC50 = 8 nM, Dmax = 89%) with minimal activity against SMARCA4 (DC50 >1 μM). Its structure comprises an (S,R,S)-AHPC-Me E3 ligase ligand, an SMI-1074-based warhead, and a defined linker. This tool compound is valuable for investigating SMARCA2-dependent biology and targeted protein degradation in cancer research models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3033586-04-5
• MW: 986.701
• Formula: C₅₆H₆₈ClN₇O₅S
• SMILES: O=C1N=C2C3(C=4C(N2C=5C1=C(Cl)C=CC5)=CC(=CC4)C6CCN(C[C@H]7CC[C@H](C(N[C@H](C(=O)N8[C@H](C(N[C@@H](C)C9=CC=C(C=C9)C=%10SC=NC%10C)=O)C[C@@H](O)C8)C(C)(C)C)=O)CC7)CC6)CCCCC3
• Target: PROTACs,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

176016893