Slingshot inhibitor D3

SKU: orb1304896

Description

JHN76359 (Slingshot inhibitor D3) is a potent and selective small molecule inhibitor of the Slingshot phosphatase family. It is a valuable research tool for studying cell migration, cytoskeletal dynamics, and related pathways in both cellular and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1715076-35-9
• MW: 461.55
• Purity: 97.87% (May vary between batches)
• Formula: C₂₅H₁₉NO₄S₂
• SMILES: Cc1ccccc1N1C(=S)S\C(=C/c2ccc(OCc3ccc(cc3)C(O)=O)cc2)C1=O
• Target: Others
• Solubility: DMSO:23.08 mg/mL (50.01 mM)

Bioactivity

• Target IC50:
  SSH:3 Μm(Slingshot 1 )|SSH:3.9 μM (Ki; Slingshot 2)
• In Vivo:
  Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells;) significantly blocks NGF-induced dephosphorylation of cofilin at 15 and 30 minutes. Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells) significantly decreases the NGF-induced cell migration, consistent with its inhibitory role in cofilin dephosphorylation. Slingshot inhibitor D3 (HEK293 cells) specifically blocks angiotensin II-induced cofilin dephosphorylation. Slingshot inhibitor D3 prevents cofilin dephosphroylation through inhibition of Slingshot.
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• In Vitro:
  Slingshot 1 had IC50 value of 3 μM and Slingshot 2 had Ki value of 3.9 μM. Slingshot inhibitor D3 has similar inhibitory activitieswith Slingshot 1 and Slingshot 2.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

potent, selective, Slingshot 1, Slingshot 2, Slingshot inhibitor D 3, Slingshot inhibitor D3, Slingshot inhibitor D-3, reversible, HEK293, PC12, inhibit, Inhibitor, JHN 76359, JHN76359, JHN-76359, competitive

Compound Identifiers

PubChem CID

154724053