SKLB-197

SKU: orb1687751

Description

SKLB-197 is a highly selective ATR inhibitor (IC50: 0.013 μM) with minimal activity against 402 other kinases. It demonstrates potent antitumor efficacy in both in vitro and in vivo models, particularly against ATM-deficient tumors, making it a valuable tool for oncology research targeting DNA damage response pathways.

Research Area

Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 2713577-16-1
• MW: 424.5
• Purity: 99.53% (May vary between batches)
• Formula: C₂₅H₂₄N₆O
• SMILES: C[C@H]1N(C=2C3=C(N=C(N2)C4=C5C(NC=C5)=CC=C4)C=CC(=C3)C=6N(C)N=CC6)CCOC1
• Target: ATM/ATR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

162641668