SKF-83566

SKU: orb1685360

Description

SKF-83566

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 99295-33-7
• MW: 332.23
• Purity: 99.82%
• Formula: C₁₇H₁₈BrNO
• SMILES: CN1CCc2cc(Br)c(O)cc2C(C1)c1ccccc1
• Target: Dopamine Receptor,AChR,5-HT Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.02 mM);DMSO:10 mM

Bioactivity

• Target IC50:
  5-HT2 receptor:11 nM (Ki)
• In Vivo:
  The facilitation induced by nicotine and cocaine can be blocked by oral administration of the dopamine D1/D5 receptor antagonist (SKF 83566)
• In Vitro:
  SKF-83566 caused a concentration-dependent increase in peak single-pulse evoked extracellular DA concentration, with a maximum increase of 65% in 5 μM SKF-83566. This was accompanied by a concentration-dependent increase in extracellular DA concentration clearance time. Both effects were occluded by nomifensine (1 μM), a dopamine transporter (DAT) inhibitor, suggesting that SKF-83566 acted via the DAT. Tested this by examining [(3)H]DA uptake into LLc-PK cells expressing rat DAT, and confirmed that SKF-83566 is a competitive DAT inhibitor with an IC(50) of 5.7 μM. Binding studies with [(3)H]CFT, a cocaine analog, showed even more potent action of SKF-83566 at the DAT cocaine binding site (IC(50) = 0.51 μM).

Storage & Handling

• Storage: store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

D5, D1, drug-related, Dopamine, Dopamine Receptor, dopamine uptake, DopamineReceptor, dorsal striatum, dentate gyrus, 5-HT2, 5-HT Receptor, 5HT Receptor, Adenylyl cyclase, Adenylate Cyclase, 5HTReceptor, 5-hydroxytryptamine Receptor, associative memory, hippocampus, parkinson's disease, nicotine craving, inhibit, Inhibitor, Serotonin Receptor, SKF83566, SKF-83566, SKF 83566

Compound Identifiers

PubChem CID

1243