SK-575-NEG

SKU: orb1982835

Description

SK-575-NEG (compound 28) is a methylated derivative of SK-575 that acts as a high-affinity PARP1 binder (IC50 = 2.64 nM) but lacks degradation activity. This control compound is useful for in vitro studies, such as distinguishing PARP1 inhibition from targeted degradation mechanisms in cancer cell lines like MDA-MB-436 and Capan-1.

Key Properties

• CAS Number: 2523017-04-9
• MW: 891
• Formula: C₄₈H₅₅FN₈O₈
• SMILES: CN1C(=O)CCC(N2C(=O)c3cccc(NCCNC(=O)CCCCCCCCCCC(=O)N4CCN(CC4)C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)c3C2=O)C1=O
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

162672785