SJB3-019A

SKU: orb1708516

Description

SJB3-019A is a novel and potent ubiquitin-specific protease 1 (USP1) inhibitor. It induces ID1 degradation, leading to significant cytotoxicity and apoptosis in K562 cells, with an IC50 of 0.0781 µM. This compound is a valuable research tool for studying DNA damage response pathways and oncology in vitro.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 2070015-29-9
• MW: 276.25
• Purity: 99.72% (May vary between batches)
• Formula: C₁₆H₈N₂O₃
• SMILES: O=C1c2nc(oc2C(=O)c2ccccc12)-c1cccnc1
• Target: DUB
• Solubility: DMSO:1 mg/mL (3.62 mM)

Bioactivity

• Target IC50:
  ID1:78.1 nM |ID1:78.1 nM
• In Vitro:
  SJB3-019A with IC50 of 0.0781 μM is 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells. SJB3-019A increases the levels of Ub-FANCD2 and Ub-PCNA, and decreases the HR activity.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ID1, SJB3 019A, SJB3019A, SJB3-019A, SJB-3-019A, USP1

Compound Identifiers

PubChem CID

78358325