Sisunatovir hydrochloride

SKU: orb1298291

Description

Sisunatovir hydrochloride (RV521 HCl) is a potent, orally bioavailable small molecule inhibitor targeting the RSV fusion (F) protein. It demonstrates strong in vitro antiviral activity against both RSV-A and RSV-B clinical isolates, with IC50 values in the low nanomolar range. This inhibitor is a valuable research tool for studying RSV entry mechanisms and for preclinical antiviral development.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 1903763-83-6
• MW: 482.9
• Purity: 99.49% (May vary between batches)
• Formula: C₂₃H₂₃ClF₄N₄O
• SMILES: Cl.NCc1ccc2n(CCCC(F)(F)F)c(CN3C(=O)C4(CC4)c4ccc(F)cc34)nc2c1
• Target: RSV
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.07 mM);DMSO:5.5 mg/mL (11.39 mM)

Bioactivity

• In Vitro:
  Sisunatovir HCl exhibited a mean IC50 of 1.2 nM against a panel of RSV A and B laboratory strains and clinical isolates with antiviral efficacy in the Balb/C mouse model of RSV infection.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

syncytial, RSV, RV 521, RV521, RV-521, RV521 HCl, Respiratory syncytial virus, respiratory, Sisunatovir, Sisunatovir HCl, Sisunatovir Hydrochloride, Sisunatovir hydrochloride, viral, inhibit, Inhibitor, antiviral

Compound Identifiers

PubChem CID

153520065