SIS17

SKU: orb1301637

Description

SIS17 is a cell-active, potent, and selective small molecule inhibitor of HDAC11, exhibiting an IC50 of 0.83 µM. It specifically blocks the demyristoylation of substrates like SHMT2 and is a valuable chemical probe for epigenetic research in oncology and immunology, applicable in both cellular and biochemical assays.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2374313-54-7
• MW: 366.6
• Purity: 98.22% (May vary between batches)
• Formula: C₂₁H₃₈N₂OS
• SMILES: CCCCCCCCCCCCCCCCNNC(=O)c1cccs1
• Target: HDAC
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.91 mM);DMSO:125 mg/mL (340.97 mM)

Bioactivity

• Target IC50:
  HDAC11:0.83 μM (IC50)
• In Vitro:
  SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, HDAC, HDAC11, Histone deacetylases, SIS 17, SIS17, SIS-17

Compound Identifiers

PubChem CID

139035087