SIRT5 inhibitor 6

SKU: orb1944442

Description

This potent and selective SIRT5 inhibitor (IC50 = 310 nM) is a research tool for studying sepsis-associated acute kidney injury. It modulates renal protein succinylation and inflammation, attenuating pathological injury and dysfunction in vivo, and is used in mechanistic studies of sirtuin biology.

Research Area

Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2834736-82-0
• MW: 460.55
• Formula: C₂₁H₂₈N₆O₄S
• SMILES: N(CCCNC(NCCC(O)=O)=S)C=1C(C(OCC)=O)=CN=C(NCC2=CC=CC=C2)N1
• Target: Sirtuin

Bioactivity

• Target IC50:
  SIRT5:3.0 μM
• In Vitro:
  SIRT5 inhibitor 6 is a selective SIRT5 inhibitor with an IC₅₀ of 3.0 μM and shows no inhibition of SIRT1–3 in vitro, indicating good selectivity.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

164628158