SIRT-IN-1

SKU: orb1309095

Description

SIRT-IN-1 is a potent small molecule inhibitor of SIRT1, SIRT2, and SIRT3 with respective IC50 values of 15, 10, and 33 μM. It is a valuable research tool for studying sirtuin biology in cellular and biochemical assays, with applications in aging, metabolism, and oncology research.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1431411-60-7
• MW: 389.52
• Purity: 99.29%
• Formula: C₁₉H₂₇N₅O₂S
• SMILES: CC(C)(C)C(=O)NCCC1CCN(CC1)c1ncnc2cc(sc12)C(N)=O
• Target: Sirtuin
• Solubility: DMSO:3.9 mg/mL (10.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.57 mM)

Bioactivity

• Target IC50:
  SIRT3:33 nM|SIRT1:15 nM|SIRT2:10 nM
• In Vitro:
  SIRT-IN-1 is one of the most potent inhibitor of truncated pan SIRT1/ 2/3(IC50 values are 0.015, 0.010, 0.033 μM, respectively). SIRT-IN-1 binds identically in the catalytic active site (RMS=0.29 ), occupying the nicotinamide C-pocket and acetyl lysine substrate channel.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SIRT1, SIRT2, SIRTIN1, SIRT-IN-1, SIRT3, SIRT IN 1, Sirtuin, inhibit, Inhibitor

Compound Identifiers

PubChem CID

71304814