Sinbaglustat

SKU: orb1690522

Description

Sinbaglustat (OGT2378) is an orally bioavailable, brain-penetrant N-alkyl iminosugar functioning as a dual inhibitor of glucosylceramide synthase (GCS) and non-lysosomal glucosylceramidase (GBA2). It is a research tool for investigating lysosomal storage disorders like Gaucher disease and related neurodegenerative pathologies in both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 441061-33-2
• MW: 233.3
• Purity: 99.93%
• Formula: C₁₁H₂₃NO₄
• SMILES: CCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO
• Target: Transferase
• Solubility: DMSO:46.66 mg/mL (200 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (21.43 mM)

Bioactivity

• In Vivo:
  Sinbaglustat (OGT2378) (2500 mg/kg/day; p.o.; in the powdered chow; corresponding to 35-40 mg/mouse/day of Sinbaglustat; Female syngeneic C57BL/6 mice and bearing MEB4 melanoma tumor, 6-8 weeks old bearing MEB4 melanoma tumor) is highly effective in impeding melanoma tumor growth in vivo. The effectiveness of p.o. Sinbaglustat in this murine model suggests that inhibition of glycosphingolipid synthesis is a promising approach to inhibit tumor progression.
• In Vitro:
  Sinbaglustat (OGT2378) (20 μM) leads to a remarkable reduction in the synthesis of glucosylceramide by 93% and ganglioside by >95% when compared to untreated MEB4 cells. This reduction occurs without inducing any cytotoxicity or antiproliferative effects. Sinbaglustat is 50-fold more potent in inhibiting GBA2 than GCS.

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

glucosylceramide synthase, OGT 2378, OGT2378, OGT-2378, ACT519276, ACT-519276, ACT 519276, Sinbaglustat

Compound Identifiers

PubChem CID

9859470