Shz 1

SKU: orb1305655

Description

Shz 1 is a small molecule cardiogenic agent that promotes cellular differentiation into a cardiac phenotype. It upregulates the expression of cardiac-specific markers, such as sarcomeric tropomyosin, making it a valuable tool for in vitro stem cell research and cardiac regeneration studies.

Research Area

Signal Transduction

Key Properties

• CAS Number: 326886-05-9
• MW: 355.21
• Purity: 99.91% (May vary between batches)
• Formula: C₁₃H₁₁BrN₂O₃S
• SMILES: Oc1ccc(Br)cc1\C=N\NS(=O)(=O)c1ccccc1
• Target: Myosin,Others
• Solubility: DMSO:4.8 mg/mL (13.51 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.82 mM)

Bioactivity

• In Vitro:
  Shz-1 showes a ~1.5-fold increase in cardiac transcripts of the Nkx2.5 gene. Shz-1 augments the expression of transcripts of the total sarcomeric TPM1 (both TPM1α & TPM1κ) and sarcomeric TPM4α. Shz-1 activates the axolotl TPM4 promoter-driven ectopic expression in C2C12 cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cardiogenic molecule, cardiac-specific, Inhibitor, inhibit, Nkx2.5 expression, Shz 1, Shz1, Shz-1, sarcomeric tropomyosin

Compound Identifiers

PubChem CID

135446537