Sertraline hydrochloride

SKU: orb1310570

Description

Sertraline hydrochloride is a selective serotonin reuptake inhibitor (SSRI) widely employed in depression research. It is utilized in both in vitro binding assays and in vivo behavioral studies to investigate serotonergic neurotransmission and antidepressant mechanisms.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 79559-97-0
• MW: 342.691
• Purity: 99.99% (May vary between batches)
• Formula: C₁₇H₁₈Cl₃N
• SMILES: Cl.CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc12
• Target: 5-HT Receptor,Serotonin Transporter
• Solubility: DMSO:61 mg/mL (178 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.84 mM)

Bioactivity

• Target IC50:
  5-HT:13 nM(Ki)
• In Vivo:
  Sertraline is more effective than fluvoxamine, zimelidine, norzimelidine, fluoxetine, or clomipramine in preferentially inhibiting the uptake of 5-HT (serotonin), with comparatively weaker inhibition of NE (norepinephrine) absorption. However, sertraline exhibits lower selectivity than these agents in blocking the uptake of 5-HT relative to DA (dopamine).
• In Vitro:
  Sertraline HCl significantly enhances locomotor activity in mice during the antidepressant Porsolt forced swim test. Intraperitoneal injection of 32 μMol/kg Sertraline HCl inhibits more than 50% of 5-hydroxytryptamine uptake by rat striatal synaptosomes. Sertraline HCl reverses 5-hydroxytryptamine depletion caused by PCA, proving to be six times more effective than chlorpromazine and sixty times more effective than amitriptyline. Acute repetitive administration of Sertraline reduces the serotonin content in whole blood. Chronic administration of Sertraline HCl in rats decreases the binding of [3H] dihydroalprenolol to cortical membranes and the cyclic AMP response to norepinephrine in the limbic forebrain adenylate cyclase.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CP-51974-1 HCl, disorder, 5-HT, 5-HTT, 5HTReceptor, 5HT Receptor, Antidepressant, obsessive, inhibit, Inhibitor, Sertraline HCl, Sertraline hydrochloride, Sertraline Hydrochloride, Sertraline, SerotoninTransporter, Serotonin Transporter, SERT, SLC6A4, SSRI

Compound Identifiers

PubChem CID

63009