Seralutinib

SKU: orb1298542

Description

Seralutinib

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1619931-27-9
• MW: 469.54
• Purity: 99.66%
• Formula: C₂₇H₂₇N₅O₃
• SMILES: COc1ccc(cc1OC)-c1cncc(N[C@@H](C)c2cccc(NC(=O)c3cncc(C)c3)c2)n1
• Target: PDGFR,c-Fms,c-Kit
• Solubility: DMSO:100 mg/mL (212.97 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.52 mM)

Bioactivity

• Target IC50:
  c-Kit:14 nM|CSF1R:8 nM
• In Vivo:
  GB002 dose- and time-dependently induces lung BMPR2 protein expression.GB002-mediated inhibition of lung PDGFRα/β phosphorylation in healthy Sprague Dawley rats immediately post inhalation.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

arterial, inhibit, Platelet-derived growth factor receptor, PDGFR, PAH, Inhibitor, hypertension, GB 002, GB002, GB-002, PDGFRα, PDGFRβ, Seralutinib, PK 10571, PK10571, PK-10571, Pulmonary

Compound Identifiers

PubChem CID

91663352