Sephin1

SKU: orb1306185

Description

Sephin1 (IFB-088) is a selective small molecule inhibitor of GADD34 (PPP1R15A). By blocking this stress-induced regulatory subunit, it prolongs eIF2α phosphorylation, thereby modulating the integrated stress response. This action has shown protective effects in preclinical models of protein misfolding diseases, such as neurodegenerative disorders.

Research Area

Metabolism Research

Key Properties

• CAS Number: 13098-73-2
• MW: 196.64
• Purity: 99.80% (May vary between batches)
• Formula: C₈H₉ClN₄
• SMILES: C(=NNC(=N)N)C1=C(Cl)C=CC=C1
• Target: Phosphatase
• Solubility: DMSO:7 mg/mL (35.6 mM);H2O:insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (5.09 mM)

Bioactivity

• In Vivo:
  Sephin1 safely prevented the motor, morphological, and molecular defects of two otherwise unrelated protein-misfolding diseases in mice, Charcot-Marie-Tooth 1B, and amyotrophic lateral sclerosis.
• In Vitro:
  Sephin1 leads to a strong attenuation of neuronal excitotoxicity independently of the integrated stress response.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(E/Z)-Icerguastat, (E/Z)-Sephin1, IFB 088, IFB088, IFB-088, NSC65390, NSC-65390, NSC 65390, inhibit, Inhibitor, Phosphatase, phosphatase PPP1R15A, PPP1R15A, PPP1R15B, Sephin-1, Sephin1, protein misfolding diseases

Compound Identifiers

PubChem CID

248404