Sennoside B

SKU: orb1305095

Description

Sennoside B is an anthranoid compound widely utilized as a laxative. It serves as a key research tool for studying constipation mechanisms and evaluating purgative effects in both in vitro assays and animal models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 128-57-4
• MW: 862.74
• Purity: 97.35%
• Formula: C₄₂H₃₈O₂₀
• SMILES: O=C1C=2C([C@@](C=3C1=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C=CC3)([C@@]5(C=6C(C(=O)C=7C5=CC=CC7O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)=C(O)C=C(C(O)=O)C6)[H])[H])=CC(C(O)=O)=CC2O
• Target: PDGFR
• Solubility: H2O:Insoluble;DMSO:125 mg/mL (144.89 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (3.83 mM)

Bioactivity

• In Vivo:
  LD50: Mice 5000 mg/kg (i.g.); Rats 5000 mg/kg (i.g.).
• In Vitro:
  Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits platelet-derived growth factor (PDGF)-stimulated MG63 cell proliferation by binding to PDGF-BB and its receptor and down-regulating the PDGFR-beta signaling pathway. Pre-incubation of PDGF-BB with sennoside B inhibits the phosphorylation of pathway components including Ak strain transforming protein (AKT), signal transducer and activator of transcription 5 (STAT-5) and extracellular signal-regulated kinase 1/2 (ERK1/2). It also inhibits bovine serum monoamine oxidase with IC50 of 9 μM.

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, PDGFR, Platelet-derived growth factor receptor, inhibit, Sennoside B

Compound Identifiers

PubChem CID

91440