Semustine

SKU: orb1706643

Description

Semustine is a DNA alkylating agent used in cancer research, particularly for studying chemotherapy mechanisms and toxicities. It is applied in experimental models of melanoma and leukemia, with research focusing on its nephrotoxic effects and antitumor activity in both in vitro and in vivo settings.

Research Area

Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 13909-09-6
• MW: 247.72
• Purity: 99.00% (May vary between batches)
• Formula: C₁₀H₁₈ClN₃O₂
• SMILES: N(C(N(CCCl)N=O)=O)C1CCC(C)CC1
• Target: DNA Alkylator/Crosslinker
• Solubility: Ethanol:45 mg/mL (181.66 mM);DMSO:90 mg/mL (363.31 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (13.32 mM)

Bioactivity

• In Vivo:
  Semustine (Me-CCNU) (150 mg×m(-2)×d(-1) once; oral; repeated every 28 days) treatment periods were within 2 - 6 months; follow-up period was 6 months. PFS at 6 months was 55.88% in the Me-CCNU group (P < 0.05). Overall survival rates at the end of the follow-up period were 97.30% in the Me-CCNU group (P > 0.05). Adverse events rates of Me-CCNU was 45.15% (P < 0.05).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Crosslinker, DNA Alkylator/Crosslinker, DNA Alkylator, DNAAlkylator, Semustine

Compound Identifiers

PubChem CID

5198