Sempervirine

SKU: orb1297210

Description

Sempervirine is a small molecule that unwinds circular DNA and selectively inhibits cancer DNA synthesis in vitro. It is used in biochemical research to study DNA topology and as a tool compound in oncology research for investigating mechanisms of DNA replication inhibition.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 6882-99-1
• MW: 273.35
• Purity: 98.81% (May vary between batches)
• Formula: C₁₉H₁₇N₂
• SMILES: C=12C=3[N+](=CC4=C(C3)CCCC4)C=CC1C=5C(N2)=CC=CC5
• Target: DNA/RNA Synthesis
• Solubility: DMSO:1.67 mg/mL (6.11 mM)

Bioactivity

• In Vitro:
  The high template in vitro activity of native DNA from cancerous mammalian and plant tissues, compared to DNA from healthy tissues, enabled us to select substances which selectively inhibit cancer DNA synthesis. Among them, alstonine, serpentine, Sempervirine and flavopereirine, all alkaloids which belong to the Beta-carboline class, distinguish cancer DNA from healthy tissue DNA inhibit DNA in vitro synthesis when native DNA from different cancerous tissues or cells is used as template. They have practically no effect on DNA from healthy tissues. The inhibitory effect of alkaloids is due to their capacity to form an 'alkaloid-cancer DNA' complex which has been characterized by use of the Sephadex column.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sempervirine, RNA Synthesis, RNASynthesis, DNASynthesis, DNA Synthesis, DNA/RNA Synthesis

Compound Identifiers

PubChem CID

165550