Semaglutide-13C6,15N TFA

SKU: orb3138760

Description

Semaglutide-13C6,15N TFA, marked with 13C and 15N isotopes, is a form of Semaglutide TFA. This compound is a long-acting, selective, competitive, orally active GLP-1R agonist capable of crossing the blood-brain barrier. Upon GLP-1R activation, it stimulates insulin secretion, inhibits gastric emptying and appetite, and enhances autophagy while reducing oxidative stress and apoptosis (apoptosis). Additionally, it modulates mitochondrial function and lipid metabolism, such as reducing hepatic de novo lipogenesis. Semaglutide TFA exhibits activities including blood glucose reduction, weight loss, neuroprotection (such as improving motor function in Parkinson’s disease models and reducing α-synuclein aggregation), and amelioration of hepatic steatosis. It is useful for research into type 2 diabetes, obesity, Parkinson’s disease, metabolic-associated steatotic liver disease (MASLD), other neurodegenerative conditions, liver diseases, and cancer.

Research Area

Immunology & Inflammation; Pharmacology & Drug Discovery

Key Properties

• Target: Apoptosis,Autophagy,Glucagon Receptor,IGF-1R,p38 MAPK,Bcl-2 Family

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Autophagy,Glucagon Receptor,IGF-1R,p38 MAPK,Bcl-2 Family