Selurampanel

SKU: orb1695232

Description

Selurampanel (BGG492) is a selective, competitive AMPA receptor antagonist of the quinazoline-dione sulfonamide class. It is an orally active research compound utilized in preclinical studies for neurological conditions such as epilepsy, migraine, and tinnitus, with applications in both in vitro receptor characterization and in vivo animal models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 912574-69-7
• MW: 377.42
• Purity: 98.68% (May vary between batches)
• Formula: C₁₆H₁₉N₅O₄S
• SMILES: C(C)(C)C1=C(C=C2C(=C1)NC(=O)N(NS(C)(=O)=O)C2=O)C=3N(C)N=CC3
• Target: iGluR
• Solubility: DMSO:27.5 mg/mL (72.86 mM)

Bioactivity

• Target IC50:
  AMPA:190 nM
• In Vivo:
  Selurampanel (3 mg/kg i.v.) a mouse plasma half-life of 3.3 h is determined, with a moderate volume of distribution (Vdss=1.3 L/kg) and a low clearance of 5.4 mL/min▪kg. Selurampanel potently and dose-dependently antagonizes maximal electroshock seizure-induced generalized tonic-clonic seizures in mice with an ED50 value around 7 mg/kg after 1 h pre-treatment.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BGG 492, BGG492, BGG-492, iGluR, Selurampanel

Compound Identifiers

PubChem CID

45381907