SEC inhibitor KL-2

SKU: orb1706646

Description

KL-2 is a potent and selective small molecule inhibitor of the super elongation complex (SEC), disrupting the AFF4-CCNT1 interaction with a Ki of 1.50 µM. This compound is a valuable chemical probe for studying transcriptional regulation in cancers and HIV latency reversal in both cellular and biochemical assays.

Research Area

Cell Biology, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 900308-51-2
• MW: 333.74
• Purity: 98.03% (May vary between batches)
• Formula: C₁₇H₁₃ClFNO₃
• SMILES: Cc1ccc(Cl)cc1NC(=O)C(\O)=C\C(=O)c1ccc(F)cc1
• Target: Others,DNA/RNA Synthesis
• Solubility: 10% DMSO+90% Corn Oil:3.3 mg/mL (9.89 mM);DMSO:75 mg/mL (224.73 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KL 2, KL2, KL-2, SEC inhibitor KL-2, SEC

Compound Identifiers

PubChem CID

75186098