SC428

SKU: orb2665279

Description

SC428 is a small molecule androgen receptor (AR) inhibitor that targets the AR N-terminal domain, effectively blocking the activity of full-length AR, splice variants, and mutants. It inhibits AR nuclear translocation, chromatin binding, and downstream gene expression, demonstrating anti-proliferative effects in vitro and tumor growth suppression in 22Rv1 xenograft models through apoptosis induction.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 1898232-70-6
• MW: 337.32
• Formula: C₁₅H₁₀F₃N₃OS
• SMILES: N#CC1=CC=C(C=C1C(F)(F)F)NC(=O)NC=CC=2SC=CC2
• Target: Apoptosis,Androgen Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

176419165