SBI-553

SKU: orb1307750

Description

SBI-553 is a potent, brain-penetrant allosteric modulator of the neurotensin receptor 1 (NTR1) with an EC50 of 0.34 µM. It is a valuable research tool for investigating NTR1 function in neurological disorders and is suitable for both in vitro binding assays and in vivo behavioral studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1849603-72-0
• MW: 450.55
• Purity: 99.69% (May vary between batches)
• Formula: C₂₆H₃₁FN₄O₂
• SMILES: COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1(F)CC1
• Target: Neurotensin Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.44 mM);DMSO:62.5 mg/mL (138.72 mM)

Bioactivity

• Target IC50:
  NTR1:(EC50)0.34 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Neurotensin Receptor, NeurotensinReceptor, NTR1, Inhibitor, SBI553, SBI-553, SBI 553

Compound Identifiers

PubChem CID

118610427