SBI-477

SKU: orb1309120

Description

SBI-477 is a chemical probe that stimulates insulin signaling by inhibiting the transcription factor MondoA. This action coordinately reduces triglyceride synthesis and increases basal glucose uptake in human skeletal myocytes, making it a useful tool for studying metabolism and insulin resistance in vitro.

Research Area

Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 781628-99-7
• MW: 483.54
• Purity: 99.30% (May vary between batches)
• Formula: C₂₄H₂₅N₃O₆S
• SMILES: COc1ccc(cc1)-c1csc(NC(=O)c2ccc(OCC(=O)N3CCOCC3)c(OC)c2)n1
• Target: Others,Arrestin,Liver X Receptor,IGF-1R
• Solubility: DMSO:45 mg/mL (93.06 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.14 mM)

Bioactivity

• In Vivo:
  SBI-477, that coordinately inhibited triacylglyceride (TAG) synthesis and enhanced basal glucose uptake in human skeletal myocytes. SBI-477 stimulated insulin signaling by deactivating the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4). Depleting MondoA in myocytes reproduced the effects of SBI-477 on glucose uptake and myocyte lipid accumulation.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MondoA, inhibit, Inhibitor, SBI 477, SBI477, SBI-477

Compound Identifiers

PubChem CID

2469116