SB269970 HCl

SKU: orb1223169

Description

SB269970 HCl, a hydrochloride salt form of SB-269970, is a 5-HT7 receptor antagonist (pKi of 8.3) and exhibits >50-fold selectivity against other receptors.

Key Properties

• CAS Number: 261901-57-9
• MW: 388.95
• Purity: >98% (HPLC)
• Formula: C₁₈H₂₈N₂O₃S·HCl
• SMILES: Cl.CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1
• Target: TRP/TRPV Channel
• Solubility: DMSO : ≥ 30 mg/mL; 77.13 mM

Bioactivity

• In Vivo:
  SB269970 hydrochloride (SB-269970A) (3-30 mg/kg; i.p.; once) significantly blocks amphetamine and ketamine-induced hyperactivity. Animal model: Male C57BL6/J mice. Dosage: 3, 10, 30 mg/kg. Administration: Intraperitoneal injection; once. Result: Significantly blocked amphetamine and ketamine-induced hyperactivity.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SB-269970A

Quick Database Links

Gene Symbol

TRP/TRPV Channel