SB 328437

SKU: orb1305666

Description

SB 328437 is a potent and selective CCR3 antagonist with an IC50 of 4.5 nM. This small molecule is a valuable research tool for studying CCR3-mediated pathways in allergic inflammation and asthma, applicable in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 247580-43-4
• MW: 378.38
• Purity: 99.54%
• Formula: C₂₁H₁₈N₂O₅
• SMILES: COC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)c1cccc2ccccc12
• Target: CCR,DNA/RNA Synthesis
• Solubility: DMSO:100 mg/mL (264.28 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (8.72 mM)

Bioactivity

• Target IC50:
  CCR3:4.5 nM (IC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(S)-methyl 2-(1-naphthamido)-3-(4-nitrophenyl)propanoate, CCR3, ZINC 29222893, ZINC29222893, ZINC-29222893, SB328437, SB-328437, SB 328437

Compound Identifiers

PubChem CID

10474776