SB 203186 hydrochloride

SKU: orb1218486

Description

SB 203186 hydrochloride is a potent 5-HT4 receptor antagonist.

Key Properties

• CAS Number: 207572-69-8
• MW: 308.81
• Purity: >98% (HPLC)
• Formula: C₁₆H₂₀N₂O₂·HCl
• SMILES: O=C(C1=CNC2=C1C=CC=C2)OCCN3CCCCC3.Cl
• Target: 5-HT Receptor
• Solubility: H2O:100 mM

Bioactivity

• In Vivo:
  Intraduodenally administered SB-203186 (0.3-3 mg/kg) to new-born Camborough piglets produced blockade of 5-HT-evoked tachycardia which was maximal after 20 min and lasted for more than 3 h with 0.3 mg/kg. SB-203186 (0.1-3 mg/kg, i. v.) surmountably antagonised 5-HT-evoked tachycardia in anaesthetized Yucatan minipigs or new-born Camborough piglets with similar potency.
• In Vitro:
  Pretreatment with SB-203186 (10 μM) enhances the 5-HT-induced contractions of the antral strips.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

5-HT Receptor