SARS-CoV-2 (COVID-19) NSP1 Protein

• Catalog Number: orb640158
• Category: Proteins
• Description: The viral nonstructural protein 1 (nsP1) is the only membrane-associated protein that anchors the replication complex to the cellular membranes. NSP1 inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.
• Reactivity: Virus
• Tag: C-10×His
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 21.7 kDa
• Target: NSP1
• Protein Sequence: YP_009725297.1
• Source: SARS-CoV-2 NSP1, His Tag (orb640158) is expressed from E. coli cells. It contains AA Met 1 - Gly 180 (Accession # YP_009725297.1).
• Expression System: E. coli
• Expression Region: Met 1 - Gly 180
• Endotoxins: 1.0 EU per μg
• NCBI: YP_009725297.1
• Storage: -20℃
• Buffer/Preservatives: PBS, Arginine, pH7.4
• Alternative names: NSP1,nsp1,Leader protein,Host translation inhibito
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.7 kDa. The protein migrates as 22-25 kDa under reducing (R) condition (SDS-PAGE).
• Expiration Date: 6 months from date of receipt.