Sarecycline free base

SKU: orb1219166

Description

Sarecycline free base is a tetracycline-derived, narrow-spectrum antibiotic.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1035654-66-0
• MW: 487.5
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₉N₃O₈
• SMILES: CN(C)[C@@H]([C@H](C[C@H](Cc1c(CNCOC)ccc(O)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O
• Target: Others
• Solubility: In Vitro: DMSO : 100 mg/mL (205.13 mM)

Bioactivity

• In Vivo:
  Animal model: Carrageenan-induced footpad edema male Sprague Dawley rats model. Dosage: 1 mg/kg, 5 mg/kg, 10 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg, 100 mg/kg, 150 mg/kg. Administration: Intraperitoneal injection (i.p.); Single dose. Before a subplantar injection of sterile 1 mg/0.1 mL carrageenan solution in the right hind paw. Result: Reduced inflammation to 55.7% and 53.1%, respectively, at doses of 75 mg/kg and 100 mg/kg compared to baseline. Animal model: Carrageenan-induced footpad edema male Sprague Dawley rats model. Dosage: 0.33, 1, 3, or 9 mg/kg. Administration: Intravenously. Result: Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32 mg/kg, respectively.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Others