SantacruzaMate A

SKU: orb1305860

Description

SantacruzaMate A (CAY-10683) is a small molecule characterized by its potent and selective inhibition of histone deacetylase (HDAC) activity. It is utilized in biochemical and cellular research to study epigenetic regulation in oncology and neurology, with applications in both in vitro assays and in vivo model systems.

Research Area

Epigenetics & Chromatin, Molecular Biology, Neuroscience

Key Properties

• CAS Number: 1477949-42-0
• MW: 278.35
• Purity: 99.55% (May vary between batches)
• Formula: C₁₅H₂₂N₂O₃
• SMILES: CCOC(=O)NCCCC(=O)NCCc1ccccc1
• Target: Beta Amyloid,HDAC
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:51 mg/mL (183.22 mM);Ethanol:51 mg/mL (183.22 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.19 mM)

Bioactivity

• Target IC50:
  HDAC6:434 nM|HDAC2:119 pM
• In Vivo:
  Santacruzamate A inhibits the growth of HCT116 colon cancer cells and HuT-78 cutaneous T-cell lymphoma cells, with GI50 values of 29.4 μM and 1.4 μM, respectively.
• Cell Research:
  HuT-78 cells incubated in Iscove’s modified Dulbecco’s medium supplemented with 20% FBS, 1% penicillin/streptomycin, and 1% L-glutamine. HCT-116 cells cultivated using McCoy’s 5A medium supplemented with 10% FBS, 1% penicillin/streptomycin, and 1% nonessential amino acids. Cells were seeded in a 96-well plate at 5000cells per well. Before treatment, the plates were incubated at 37°C, 5% CO2 for 24 h. Treatment with inhibitors were incubated in wells for 72 or 96 h using SAHA as a positive control. Antiproliferative activity was determined using a standard MTS-PMS assay. (Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CAY 10683, CAY10683, CAY-10683, HDAC, HDAC2, HDAC4, HDAC6, Histone deacetylases, inhibit, Inhibitor, SantacruzaMate A

Compound Identifiers

PubChem CID

72946782