Sangivamycin

SKU: orb1297988

Description

Sangivamycin

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 18417-89-5
• MW: 309.28
• Purity: 98.11% (May vary between batches)
• Formula: C₁₂H₁₅N₅O₅
• SMILES: NC(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2ncnc(N)c12
• Target: Nucleoside Antimetabolite/Analog,PKC
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.67 mM);DMSO:120 mg/mL (388 mM)

Bioactivity

• Target IC50:
  PKC:10 μM(Ki)
• In Vitro:
  Sangivamycin (0.3 μM; 0-72 hours) exhibits a predominantly cytocidal effect in multidrug-resistant MCF7/adriamycin-resistant (ADR) human breast carcinoma cells, and a cytostatic effect in drug-sensitive MCF7/wild type (WT) cells. In MCF7/ADR cells, Sangivamycin triggers caspase activation, leading to significant cleavage of lamin A into a 28-kDa fragment within 48 hours. These findings highlight Sangivamycin's differential antitumor activities, inducing apoptosis-driven cell death in MCF7/ADR cells and growth arrest in MCF7/WT cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cells, antiproliferative, antitumor, analog, Analog, BA 90912, BA90912, BA-90912, Inhibitor, MCF7, inhibit, NSC 65346, NSC65346, NSC-65346, NucleosideAntimetabolite, nucleoside, Nucleoside Antimetabolite, Nucleoside Antimetabolite/Analog, Sangivamycin, PKC, Protein kinase C

Compound Identifiers

PubChem CID

14978