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S29434

SKU: orb1220483

Description

S29434 (NMDPEF) is a potent competitiveinhibitor of quinone reductase 2 (QR2;IC50:5-16nM).

Images & Validation

Key Properties

CAS Number874484-20-5
MW374.39
Purity>98% (HPLC)
FormulaC21H18N4O3
SMILESCOc1ccc2n3Cc4cccnc4-c3c(CCNC(=O)c3ccco3)c2n1
TargetNADPH
SolubilityDMSO:12.5 mg/mL (33.39 mM)

Bioactivity

In Vivo
Animal model: CH3 wild-type mice. Dosage: 1 and 15 mg/kg. Administration: Intraperitoneal injection; 1 and 15 mg/kg once. Result: Positively affected memory by inhibiting QR2.
In Vitro
Cell Autophagy Assay Cell line: HepG2 cell line. Concentration: 5 and 10 μM. Incubation time: 24 hours. Result: Mitochondrial ROS-independently and QR2-dependently triggered autophagy, and dose-dependently induced LC3-II which is a marker of autophagy vesicles.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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S29434 (orb1220483)

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Available Sizes

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100 mg
200 mg
500 mg
5 mg
$ 210.00
10 mg
$ 320.00
25 mg
$ 620.00
50 mg
$ 920.00