(S)-UFR2709 hydrochloride

SKU: orb1693170

Description

(S)-UFR2709 hydrochloride is a potent and selective antagonist of α4β2 and α7 nicotinic acetylcholine receptors (nAChRs). It exhibits anxiolytic activity and serves as a valuable research tool for investigating nicotine addiction mechanisms in both in vitro and in vivo experimental models.

Research Area

Neuroscience

Key Properties

• CAS Number: 2934318-93-9
• MW: 255.74
• Purity: 98.94% (May vary between batches)
• Formula: C₁₃H₁₈ClNO₂
• SMILES: C(OC(=O)C1=CC=CC=C1)[C@H]2N(C)CCC2.Cl
• Target: AChR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.82 mM);DMSO:50 mg/mL (195.51 mM)

Bioactivity

• In Vivo:
  (S)-UFR2709 (hydrochloride) (50-100 μg/ml) administered for 3 minutes and then held for 5 minutes significantly reduces bottom dwelling time in the Novel Tank Test (NTT), showing a dose-dependent decrease to 52.9 and 87.0 seconds for 50 and 100 μg/ml, respectively . This compound also diminishes nicotine-evoked mRNA expression of the α4 nACh receptor subunit in adult zebrafish brains, with a lesser effect at both concentrations . Additionally, intraperitoneal injection at 1-10 mg/kg daily for 17 days in high-alcohol-drinking UChB rats significantly decreases ethanol consumption and preference, while increasing water consumption dose-dependently, with 2.5 mg/kg being the most effective, resulting in a 56% reduction in alcohol intake, without impacting weight or locomotor activity .
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• In Vitro:
  Brain nicotinic acetylcholine receptors (nAChRs), a diverse group of pentameric acetylcholine-gated cation channels, serve as a molecular target for alcohol abuse and dependence treatment.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

nAChR, (S)UFR2709 hydrochloride, (S)-UFR2709 hydrochloride, (S)-UFR-2709 hydrochloride, (S) UFR2709 hydrochloride, UFR 2709 Hydrochloride, UFR2709 Hydrochloride, UFR-2709 Hydrochloride

Compound Identifiers

PubChem CID

162642465