(S)-Malic acid

SKU: orb1302522

Description

(S)-Malic acid is a dicarboxylic acid found in foods like apples and is a key metabolic intermediate. Its ionized form, malate, is crucial in the TCA cycle and cellular energy production, serving roles in redox shuttles and anaerobic metabolism. This compound is used in research on mitochondrial function, exercise physiology, and metabolic pathways in both in vitro and in vivo models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 97-67-6
• MW: 134.09
• Purity: 98.00% (May vary between batches)
• Formula: C₄H₆O₅
• SMILES: [C@H](CC(O)=O)(C(O)=O)O
• Target: Endogenous Metabolite
• Solubility: DMSO:123.75 mg/mL (922.89 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (14.92 mM)

Bioactivity

• In Vitro:
  It is shown that ME is essential for (S)-Malic acid (L-malic acid) utilization in L. casei. Moreover, deletion of either the gene encoding the histidine kinase or the response regulator of the TC system resulted in the loss of the ability to grow on (S)-Malic acid, thus indicating that the cognate TC system regulates and is essential for the expression of ME. Transcriptional analyses shows that expression of maeE is induced in the presence of (S)-Malic acid and repressed by glucose, whereas TC system expression is induced by (S)-Malic acid and is not repressed by glucose.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, L-Malic acid, L-(-)-Malic acid, inhibit, HYDROXYSUCCINIC ACID, Malic acid, Endogenous Metabolite, EndogenousMetabolite, 2-Hydroxysuccinic acid, (S) Malic acid, (S)-2-Hydroxysuccinic acid, (S)-E 296, (S)-Hydroxybutanedioic acid, (S)-(-)-HYDROXYSUCCINIC ACID, (S)Malic acid, (S)-Malic acid

Compound Identifiers

PubChem CID

222656