(S)-HH2853

SKU: orb1744421

Description

(S)-HH2853 is a potent and selective dual inhibitor of EZH1 and EZH2, demonstrating sub-100 nM IC50 against the EZH2_Y641F mutant. This compound exhibits antitumor activity in preclinical models and serves as a valuable chemical probe for researching oncology and autoimmune disease mechanisms in both cellular and animal studies.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2202678-05-3
• MW: 611.66
• Purity: 99.74%
• Formula: C₃₁H₃₆F₃N₇O₃
• SMILES: [C@H](C)(C=1N2C(=C(C=C2)C3=CC=C(C)N=N3)C=C(C(NCC4=C(OC)C=C(C)NC4=O)=O)C1C)N5CCN(CC(F)(F)F)CC5
• Target: Histone Methyltransferase

Bioactivity

• Target IC50:
  EZH2 (Y641N):<100 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Histone Methyltransferase, HistoneMethyltransferase, EZH2

Compound Identifiers

PubChem CID

139311483