S 18986

SKU: orb1706676

Description

S 18986 is an orally bioavailable, brain-penetrant positive allosteric modulator of AMPA receptors. It enhances cognition in rodent models by potentiating glutamatergic signaling and increasing hippocampal acetylcholine and noradrenaline release, as demonstrated in object recognition memory tests.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 175340-20-2
• MW: 224.28
• Purity: 99.64%
• Formula: C₁₀H₁₂N₂O₂S
• SMILES: O=S1(=O)C=2C(N3[C@@](N1)(CCC3)[H])=CC=CC2
• Target: GluR,iGluR
• Solubility: DMSO:60 mg/mL (267.52 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (11.15 mM)

Bioactivity

• In Vivo:
  S 18986 displays antiamnesic properties in middle-aged rodents in spatial memory models. S 18986 is robust memory-enhancing effects in middle-aged animals compared with aged ones. S 18986 (5-50 mg/kg; i.p.) obviously enhances both the induction and the maintenance of 4 and 20 bursts tetanus-evoked potentiation .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMPA, S 18986, S18986, S-18986

Compound Identifiers

PubChem CID

637863