Rufigallol

SKU: orb1741524

Description

Rufigallol is an electron-deficient, disk-shaped anthraquinone derivative that functions as a versatile building block for inducing discotic liquid crystal (DLC) phases and conferring aggregation-induced emission (AIE) properties. It has demonstrated synergistic in vitro and in vivo antimalarial activity, particularly in combination with agents like vitamin C, making it a compound of interest for materials science and antiparasitic research.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 82-12-2
• MW: 304.21
• Purity: 99.96%
• Formula: C₁₄H₈O₈
• SMILES: O=C1C=2C(C(=O)C=3C1=CC(O)=C(O)C3O)=CC(O)=C(O)C2O
• Target: Reactive Oxygen Species,Parasite,ROS
• Solubility: DMSO:3.17 mg/mL (10.42 mM)

Bioactivity

• In Vivo:
  Rufigallol, an anthraquinone derivative and exifone, a benzophenone derivative, in vitro, have remarkable synergistic antimalarial. We carried out antimalarial testing, in combination with rufigallol, in mice infected with Plasmodium berghei. Nine ketones, out of 20, showed good antimalarial activity, in vivo, when tested in combination with rufigallol, indicating the synergism between them.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AI 300865, AI300865, AI-300865, AI3-00865, AI3 00865, antimalarial, P. falciparum, Rufigallol

Compound Identifiers

PubChem CID

65737