RS 61443

SKU: orb1310798

Description

RS 61443 (Mycophenolate mofetil) is a selective immunosuppressive agent that reversibly inhibits inosine monophosphate dehydrogenase (IMPDH). It is widely used in research involving transplant immunology and autoimmune disease models, both in vitro and in vivo, to study lymphocyte proliferation and immune response modulation.

Research Area

Metabolism Research

Key Properties

• CAS Number: 115007-34-6
• MW: 433.5
• Purity: 99.96%
• Formula: C₂₃H₃₁NO₇
• SMILES: O=C(OCCN1CCOCC1)CC/C(C)=C/CC2=C(O)C3=C(COC3=O)C(C)=C2OC
• Target: Dehydrogenase
• Solubility: DMSO:11 mg/mL (25.37 mM)

Bioactivity

• In Vitro:
  Mycophenolate mofetil (MMF) is a relatively new systemic immunosuppressive agent whose use is rapidly increasing within the field of dermatologic. Originally used in the 1970s for the treatment of psoriasis, MMF has demonstrated efficacy in multiple types of inflammatory skin diseases. Although the safety data within the dermatologic literature is sparse, MMF's extensive use within the field of organ transplantation has demonstrated a favorable safety profile. MMF's lack of hepatic or renal toxicity is a significant advantage over immunosuppressive medications currently used in dermatology and make MMF an attractive candidate for multidrug regimens.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IMPDH, Mycophenolate mofetil, TM-MMF, RS 61443, RS61443, RS-61443

Compound Identifiers

PubChem CID

5281078